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Superantigens

Superantigens PDF

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Author: Bernhard Fleischer
Publisher: Springer Science & Business Media
ISBN: 3642509983
Size: 75.61 MB
Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 137
View: 4815


This volume of Current Topics in Microbiology and Immunology is concerned with a class of molecules that are the most potent polyclonal stimulators of T lymphocytes of several species. These molecules have been named "superantigens" because they use a mechanism of T cell stimulation closely mimicking MHC-restricted recognition of specific antigen: they act on variable parts of T cell antigen receptors and are presented by MHC class II molecules. Prototypes of these molecules are the pyrogenic exotoxins produced by S. aureus and S. pyogenes, of which the staphylococcal enterotoxins and the toxic shock syndrome toxin are the best known. Superantigens also occur endogen ously in mice, most notably the enigmatic Mis determinants, that have withstood characterization for nearly 20 years. Only very recently was it found that Mis is probably encoded by endogenous retroviruses. The list of candidates that are implicated as being superantigens is growing. In many cases, however, the proof that a given molecule indeed falls into this category is still missing.

Streptococcal Superantigens

Streptococcal Superantigens PDF

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Author: Anshu Babbar
Publisher: Springer
ISBN: 3319224557
Size: 60.88 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 41
View: 3483


This book provides ample knowledge and better understanding of Streptococcus pyogenes and their superantigens. Many illustrations make this a highly informative book. This book elucidates briefly Streptococcus pyogenes as a strict human pathogen possessing an array of virulence factors. These help in evading host immune responses such as by the activation of non-specific T-cell subpopulations by producing superantigens. This book mainly focuses on streptococcal superantigens and explains how they are different from conventional antigens. Moreover, it elaborates those diseases in which superantigens are actively involved. Useful aspects of superantigens and different therapeutic interventions to eradicate superantigens induced diseased are also discussed.

Superantigen Protocols

Superantigen Protocols PDF

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Author: Teresa Krakauer
Publisher: Springer Science & Business Media
ISBN: 1592593674
Size: 14.10 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 260
View: 5859


Leading researchers in the biological, chemical, and physical investigation of superantigens describe in step-by-step detail their best experimental techniques to assess the physical characteristics and biological effects of superantigens. Their protocols range from those for investigating the interactions of superantigens with cellular receptors to those for the analysis of their immunological and biological effects, including methods for using BIOcore to determine binding kinetics and establishing various lymphocyte cell culture systems. There are also accounts of such methods as the RNase protection assay, cytokine ELISA, FACS analysis, and cytokine production at the single cell level..

Superantigene Als Pathogenit Tsmechanismus Unter Besonderer Ber Cksichtigung Des Mycoplasma Arthritidis Superantigens

Superantigene als Pathogenit  tsmechanismus unter besonderer Ber  cksichtigung des Mycoplasma arthritidis Superantigens PDF

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Author: Lothar Rink
Publisher:
ISBN:
Size: 55.57 MB
Format: PDF, Kindle
Category :
Languages : de
Pages : 100
View: 837



Superantigens

Superantigens PDF

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Author: Amanda J. Brosnahan
Publisher: Humana Press
ISBN: 9781493980260
Size: 33.66 MB
Format: PDF
Category : Medical
Languages : en
Pages : 228
View: 5194


This volume combines protocols that encompass the true variety of investigation done on superantigens in the fields of microbiology, immunology, molecular biology, biochemistry, and cellular biology, with a strong focus on disease models utilized to determine the role of superantigens in human disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Superantigens: Methods and Protocols contains a detailed and wide breadth of subject coverage that any scientist, clinician, or industry professional interested in this field will find valuable.

Superantigens And Superallergens

Superantigens and Superallergens PDF

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Author: Gianni Marone
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805582668
Size: 10.22 MB
Format: PDF
Category : Medical
Languages : en
Pages : 243
View: 6836


Superantigens constitute a growing family of bacterial and viral proteins that share the capacity of inducing massive activation of the immune system. This volume contains contributions from leaders in the field of classical T cell superantigens and sheds light on relevant B cell superantigens at the molecular and biochemical levels. This is the first volume to put together basic and clinical aspects of the classical T cell superantigens, B cell superantigens and superallergens. It will therefore be indispensable reading to basic and clinical immunologists, microbiologists, virologists and specialists in allergic and immune disorders.

Arthritis Nach Expression Des Superantigens Staphylokokkenenterotoxin A Sea Im Kniegelenk Der Lewis Ratte

Arthritis nach Expression des Superantigens Staphylokokkenenterotoxin A  SEA  im Kniegelenk der Lewis Ratte PDF

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Author:
Publisher:
ISBN:
Size: 15.35 MB
Format: PDF, Mobi
Category :
Languages : de
Pages : 144
View: 5382


Superantigen; Staphylokokken-Enterotoxin A (SAG); Arthritis; Humane endogene Retroviren (HERV); Envolope Protein; T-Zell Antigen; Pathogenese; Lewis-Ratte; Lymphozyten; V-[beta]-spezifisch

Superantigens

Superantigens PDF

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Author: Leung
Publisher: CRC Press
ISBN: 9780824798130
Size: 11.76 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 624
View: 4938


This up-to-date sourcebook covers viral and bacterial superantigens (SAgs) from molecular structure and immunological processes to pathology and treatment of superantigen-mediated human diseases. Discusses diseases beyond Toxic Shock Syndrome, such as autoimmune and inflammatory skin conditions, as well as the role of superantigens in other infectious diseases. Illustrated with molecular structures of superantigens.

Superantigens

Superantigens PDF

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Author: Bernhard Fleischer
Publisher: Springer
ISBN: 9783642509995
Size: 54.22 MB
Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 137
View: 2643


This volume of Current Topics in Microbiology and Immunology is concerned with a class of molecules that are the most potent polyclonal stimulators of T lymphocytes of several species. These molecules have been named "superantigens" because they use a mechanism of T cell stimulation closely mimicking MHC-restricted recognition of specific antigen: they act on variable parts of T cell antigen receptors and are presented by MHC class II molecules. Prototypes of these molecules are the pyrogenic exotoxins produced by S. aureus and S. pyogenes, of which the staphylococcal enterotoxins and the toxic shock syndrome toxin are the best known. Superantigens also occur endogen ously in mice, most notably the enigmatic Mis determinants, that have withstood characterization for nearly 20 years. Only very recently was it found that Mis is probably encoded by endogenous retroviruses. The list of candidates that are implicated as being superantigens is growing. In many cases, however, the proof that a given molecule indeed falls into this category is still missing.

Viral Superantigens

Viral Superantigens PDF

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Author: Kyuhei Tomonari
Publisher: CRC Press
ISBN: 9780849376887
Size: 30.65 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 276
View: 4726


Since the discovery of viral superantigens in 1991, immunologists have made a number of new discoveries. The discoveries, especially those relating to the interplay between the immune system and viruses producing superantigens, have had a great impact on immunology and virology, as it appears that some diseases are triggered or exacerbated by viral superantigens. Viral Superantigens presents a complete review of this new area of study. Edited by a leading researcher and authored by a distinguished team of contributors, this comprehensive analysis covers every aspect of viral superantigens and related subjects, including critical topics such as effects on the T cell repertoire and viral superantigen-mediated diseases. Immunologists and virologists, clinical practitioners, and graduate students will find this book an invaluable resource to encourage further advances in research.

Charakterisierung Der Eigenschaften Des Mycoplasma Arthritidis Superantigens

Charakterisierung der Eigenschaften des Mycoplasma arthritidis Superantigens PDF

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Author: Markus Diedershagen
Publisher:
ISBN:
Size: 16.11 MB
Format: PDF, ePub, Mobi
Category :
Languages : de
Pages : 149
View: 581



Superantigens

Superantigens PDF

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Author: Brigitte T. Huber
Publisher: CSHL Press
ISBN: 9780879693985
Size: 14.29 MB
Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 182
View: 6239


Superantigens are microbial products that defy the conventional notion of lymphocyte activation to produce an unusually vigorous, genetically unrestricted response among many subsets of antigen-specific T cells. Bacterial toxins and certain viral gene products behave as superantigens, deleting T cells in vivo and stimulating their proliferation in vitro. These observations raise many fascinating questions about the nature of T-cell activation and microbial pathogenesis. This volume is an up-to-date, wide-ranging examination of the function and significance of superantigens in virology, biochemistry, and cell and stuctural biology as well as immunology. The book will interest graduate students and postdoctoral fellows in a wide range of biomedical sciences.

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